Telehealth-Adapted Compensatory Training and Intervention for Cognition

Summary

The goal of this clinical trial is to develop a five-week virtual cognitive training intervention for people with Mild Cognitive Impairment (MCI) based off an existing eight-week intervention. The main question it aims to answer is:

• Is five weeks of training as good as eight weeks in improving cognition, quality of life, daily functioning, and mood, and in reducing caregiver burden? Researchers will compare five weeks of cognitive training to eight weeks of training to see if the shorter version is as effective as the full training.

Participants will complete all activities virtually:

* Complete a screening visit with a study partner (typically a family member, roommate, or close friend) to determine eligibility to participate in the study
* Complete some tests of memory and thinking and some questionnaires
* Attend weekly two-hour group cognitive training sessions with a trained group leader, for five or eight weeks
* Redo the questionnaires and tests of memory and thinking immediately after completing the training, and three months after completing the training

Conditions

• MCI
• Mild Cognitive Impairment
• Mild Cognitive Impairment (MCI)

Interventions

BEHAVIORAL

Motivationally Enhanced Compensatory Cognitive Training for Mild Cognitive Impairment (ME-CCT-MCI)

ME-CCT-MCI is a publicly available manual for people with mild cognitive impairment (MCI) which has shown effectiveness in improving cognitive performance. Course material will be from the manualized protocol by Huckans and Twamley et al. (2018). The manual includes brief motivational interviewing techniques and modules designed to support behaviors that enhance cognition, such as physical activity, strategies to support learning and memory, mindfulness, and the use of day planners and calendars. It includes the use of frequent breaks, and at-home practice exercises. Each weekly session will be completed in groups of 8-10 participants, and will be led by trained intervention leaders.

BEHAVIORAL

Brief Motivationally Enhanced Compensatory Cognitive Training for Mild Cognitive Impairment (bME-CCT-MCI)

bME-CCT-MCI is a shortened version of the full ME-CCT-MCI, from eight weeks to five weeks. It preserves core principles of cognitive compensation and habit learning, with a booster summary session in week 5 to reinforce retention. Other than the condensed material, sessions are the same as those in the full ME-CCT-MCI.

Sponsors & Collaborators

• University of Florida

  lead OTHER

Principal Investigators

• Cameron K Perrin, M.S. · University of Florida

• Joseph M Gullett, Ph.D. · University of Florida

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-04-30

Primary Completion

2027-06-30

Completion

2027-08-31

Countries

• United States

Study Locations