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Second-Generation Laryngeal Mask Airway vs Endotracheal Intubation in Adult Liver Transplantation

NCT07775521 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2026-08-20

No results posted yet for this study

Summary

This prospective, multicenter, randomized controlled trial aims to evaluate the safety and feasibility of second-generation laryngeal mask airway (LMA) management compared with conventional endotracheal intubation (ETT) during general anesthesia in adults undergoing elective liver transplantation. Approximately 100 participants undergoing their first elective liver transplantation will be randomly assigned in a 1:1 ratio to either the LMA group or the ETT group. The study will primarily evaluate a composite endpoint of intraoperative airway-related adverse events, including clinically significant airway leakage, pulmonary aspiration, laryngospasm, bronchospasm, and airway injury. Conversion from LMA to endotracheal intubation, perioperative hemodynamic changes, blood gas measurements, airway placement and removal times, postoperative airway symptoms, pulmonary complications, intensive care unit length of stay, and postoperative hospital length of stay will also be assessed. Participants will be followed during hospitalization and for 3 months after transplantation to evaluate safety, postoperative recovery, rehospitalization, and survival.

Conditions

  • Liver Allograft

Interventions

PROCEDURE

Second-Generation Laryngeal Mask Airway

After induction of general anesthesia and adequate neuromuscular blockade, an appropriately sized second-generation laryngeal mask airway will be inserted by an experienced anesthesiologist and connected to a mechanical ventilator.

PROCEDURE

Endotracheal Intubation Airway Management

After induction of general anesthesia and adequate neuromuscular blockade, conventional oral endotracheal intubation will be performed by an experienced anesthesiologist using an appropriately sized endotracheal tube. After correct tube placement is confirmed by end-tidal carbon dioxide monitoring and symmetric breath sounds, the tube will be connected to a mechanical ventilator.

Sponsors & Collaborators

  • Guangzhou Medical University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-08-03
Primary Completion
2027-04-30
Completion
2027-07-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07775521 on ClinicalTrials.gov