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Ureterolysis in Laparoscopic Total Hysterectomy: Routine Approach

NCT07774858 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 35000

Last updated 2026-08-26

No results posted yet for this study

Summary

This randomized controlled trial will compare routine bilateral ureterolysis with selective ureterolysis during total laparoscopic hysterectomy for benign gynecological conditions. Participants will be allocated to either routine ureter identification and dissection before uterine vessel ligation or selective ureterolysis performed only when predefined intraoperative safety triggers are present. The primary outcome will be the incidence of recognized and unrecognized ureteric injury, while secondary outcomes will include operative time, blood loss, other perioperative complications, conversion to laparotomy, length of hospital stay, and postoperative recovery.

Conditions

  • Hysterectomy
  • Laparoscopic Surgery

Interventions

PROCEDURE

Routine Ureterolysis

Bilateral ureterolysis is systematically performed before uterine vessel ligation to identify and protect both ureters.

PROCEDURE

Selective Ureterolysis

Ureterolysis is performed only when predefined intraoperative indications are present, such as distorted anatomy, poor ureteric visualization, dense adhesions, endometriosis, active bleeding, or concern regarding ureteric safety.

Sponsors & Collaborators

  • ClinAmygate

    lead OTHER

Principal Investigators

  • Khaled AA ElSetohy, MD · Cairo University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
35 Years
Max Age
70 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-09-16
Primary Completion
2032-12-01
Completion
2033-03-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07774858 on ClinicalTrials.gov