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Effect of Early Versus Late Premolar Extraction on Orthodontic Tooth Movement

NCT07773389 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 26

Last updated 2026-08-19

No results posted yet for this study

Summary

The goal of this randomized controlled trial is to evaluate whether the timing of premolar extraction affects the rate of orthodontic space closure during en-masse anterior retraction. The study will also assess gingival cleft formation, mesial movement of the upper first molars, ease and duration of premolar extraction, and patient-reported pain and anxiety.

The main question it aims to answer is:

Does early versus late premolar extraction affect the rate of orthodontic space closure?

Researchers will compare two groups of patients. In the early extraction group the maxillary first premolars will be extracted before or within one week of start of fixed orthodontic treatment. In the late extraction group, the premolars will be extracted after alignment and immediately before the start of space closure.

Participants will:

* Receive fixed orthodontic treatment and bilateral extraction of the maxillary first premolars.
* Be randomly assigned to either the early-extraction or late-extraction group.
* Undergo orthodontic alignment followed by en-masse anterior retraction.
* Have dental impressions/digital models obtained at the start of retraction and at 3 and 6 months to measure orthodontic tooth movement and space closure.
* Be assessed for gingival clefts and mesial movement of the upper first molars.
* Have the ease and duration of their premolar extraction recorded and report their pain and anxiety associated with the extraction procedure.

Conditions

  • Malocclusion Class II
  • Malocclusion, Angle Class I

Interventions

PROCEDURE

Early Maxillary First Premolar Extraction

Bilateral extraction of the maxillary first premolars will be performed prior to or within one week of fixed orthodontic appliance placement, allowing the extraction sockets to heal during leveling and alignment before commencement of en-masse anterior retraction.

PROCEDURE

Late Maxillary First Premolar Extraction

Bilateral extraction of the maxillary first premolars will be performed after completion of leveling and alignment and one month of stabilization on a 0.019 × 0.025-inch stainless steel archwire, immediately before commencement of en-masse anterior retraction.

Sponsors & Collaborators

  • Shifa College of Dentistry

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
13 Years
Max Age
25 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-07-22
Primary Completion
2028-01-31
Completion
2028-06-30

Countries

  • Pakistan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07773389 on ClinicalTrials.gov