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Platelet-Rich Fibrin as an Antibiotic Delivery Vehicle in Mandibular Third Molar Surgery

NCT07764757 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 31

Last updated 2026-08-14

No results posted yet for this study

Summary

The present study aims to evaluate the effect of platelet-rich fibrin (PRF) used as a local antibiotic delivery vehicle on postoperative outcomes, including facial swelling, trismus, and pain, following mandibular third molar surgery in a randomized split-mouth clinical trial.

Conditions

  • Facial Swelling
  • Tooth Position Anomalies
  • Tooth, Impacted
  • Tooth Extraction Status Nos
  • Tooth Avulsion

Interventions

BIOLOGICAL

Antibiotic-enriched Platelet-Rich Fibrin (PRF)

Platelet-rich fibrin prepared with the addition of antibiotic prior to centrifugation and applied into the mandibular third molar extraction socket to provide local antibiotic delivery.

BIOLOGICAL

Platelet-Rich Fibrin (PRF)

Standard platelet-rich fibrin prepared without antibiotic addition and applied into the mandibular third molar extraction socket.

Sponsors & Collaborators

  • Amerigo Giudice

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
32 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-11-01
Primary Completion
2026-09-01
Completion
2026-11-20

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07764757 on ClinicalTrials.gov