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Effect of Platelet-Rich Fibrin on Postoperative Pain, Trismus, and Edema After Mandibular Third Molar Surgery

NCT07672951 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 134

Last updated 2026-06-29

No results posted yet for this study

Summary

Impacted mandibular third molars are among the most commonly encountered conditions in oral and maxillofacial surgery. Surgical removal of these teeth is frequently associated with postoperative complications such as pain, facial swelling, and trismus, which may affect patients' daily activities and quality of life.

Platelet-rich fibrin (PRF) is an autologous platelet concentrate prepared from the patient's own blood and contains various growth factors that may promote wound healing and reduce postoperative inflammation. The present randomized controlled trial aims to evaluate the effectiveness of PRF in reducing postoperative pain, trismus, and facial swelling after surgical removal of mandibular third molars.

Participants with impacted mandibular third molars meeting the eligibility criteria will be randomly allocated into two groups. The intervention group will receive PRF placement in the extraction socket, while the control group will receive sterile absorbable gelatin sponge (Gelfoam) after tooth removal. Postoperative pain, mouth opening, and facial swelling will be assessed preoperatively and on the first and seventh postoperative days.

The findings of this study may help determine whether PRF improves postoperative recovery following mandibular third molar surgery.

Conditions

  • Impacted Mandibular Third Molar
  • Postoperative Pain
  • Trismus
  • Edema Face

Interventions

BIOLOGICAL

Platelet-rich fibrin (PRF)

Platelet-rich fibrin (PRF) will be prepared from 10 mL of autologous venous blood collected from the participant. The blood sample will be centrifuged at 2700 rpm for 12 minutes to obtain the fibrin clot. Following surgical extraction of the mandibular third molar, the PRF clot will be placed into the extraction socket before wound closure.

DEVICE

Sterile Absorbable Gelatin Sponge

Following surgical extraction of the mandibular third molar, a sterile absorbable gelatin sponge (Gelfoam) will be placed into the extraction socket before wound closure. Standard postoperative medications and instructions will be provided to all participants.

Sponsors & Collaborators

  • PAEC General Hospital, Islamabad

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-12-09
Primary Completion
2026-05-16
Completion
2026-05-22

Countries

  • Pakistan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07672951 on ClinicalTrials.gov