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Intraoperative Dexmedetomidine Use and Postoperative Delirium After Cardiac Surgery

NCT07759297 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 5468

Last updated 2026-08-12

No results posted yet for this study

Summary

The goal of this observational study is to evaluate whether intraoperative dexmedetomidine use is associated with postoperative delirium in adults undergoing cardiac surgery. The study includes two linked components. First, researchers will analyze routinely collected clinical data from patients who underwent cardiac surgery at Tongji Hospital between January 2015 and December 2025. Second, archived plasma samples from a previously established observational cohort will be tested for matrix metalloproteinase-8 (MMP-8), a blood protein involved in inflammation and tissue injury. Researchers will compare patients who received dexmedetomidine during surgery with patients who did not receive dexmedetomidine. The decision to administer dexmedetomidine was made by the attending anesthesiologist based on the patient's clinical condition and routine anesthetic practice and was not assigned by the study protocol. The study will examine the associations among intraoperative dexmedetomidine use, perioperative changes in MMP-8, and postoperative delirium.

Conditions

  • Postoperative Delirium

Interventions

DRUG

Dexmedetomidine

Documented intraoperative administration of dexmedetomidine during cardiac surgery with cardiopulmonary bypass. The decision to administer dexmedetomidine was made by the attending anesthesiologist based on the patient's clinical condition and routine anesthesia practice and was not assigned by the study protocol. No standardized dexmedetomidine dose, timing, or duration was assigned by the study protocol.

Sponsors & Collaborators

  • Shusheng Li

    lead OTHER

Principal Investigators

  • Qin Zhang · Tongj Hospital, Tongji Medical College, Huazhong University of Science and Technology

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-04-01
Primary Completion
2025-12-30
Completion
2026-01-03

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07759297 on ClinicalTrials.gov