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Dynamics of Wound Healing in Patients With Obesity

NCT07756112 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 104

Last updated 2026-08-10

No results posted yet for this study

Summary

Healing after dental surgery can vary from person to person. This study is being done to understand how body weight (obesity vs. normal weight) may affect healing after tissue is removed from the roof of the mouth during a gum graft procedure. The study will also evaluate whether a healing material made from a participant's own blood, called platelet-rich fibrin (PRF), is comparable in quantity and quality to the standard-of-care collagen plug.

First, participants will be classified into obese or normal weight groups. Next, participants will be randomized to receive either collagen plug or platelet-rich fibrin clot during their surgical procedure Then, participants will return for 4 visits up to 30 days from the surgery visit.

Conditions

  • Wound Healing

Interventions

PROCEDURE

Collagen Plug (standard of care)

Collagen Plug (standard of care)

PROCEDURE

Platelet-Rich Fibrin Clot

Platelet-Rich Fibrin Clot is placed on wound

Sponsors & Collaborators

  • University of Iowa

    lead OTHER

Principal Investigators

  • Sukirth E Ganesan, DDS,PhD,MPH · University of Iowa College of Dentistry and Dental Clinics

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-08-31
Primary Completion
2029-08-31
Completion
2029-08-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07756112 on ClinicalTrials.gov