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Chitosan and i-PRF in Palatal Wound Healing

NCT07072546 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 68

Last updated 2026-01-27

No results posted yet for this study

Summary

This study aims to evaluate the effects of chitosan and injectable platelet-rich fibrin (i-PRF) on wound healing at the donor site following free gingival graft (FGG) procedures. The palatal donor area often experiences delayed healing and postoperative discomfort, motivating the search for effective biomaterials to enhance recovery and reduce patient morbidity. Although various approaches have been investigated, the combined application of chitosan and i-PRF has not yet been explored in this context.

The study examines three patient groups treated at the periodontology departments of Çukurova and Biruni University: one with gelatin sponge (control), one with chitosan, and one with chitosan infused with i-PRF. Parameters such as pain (VAS), bleeding, burning sensation, dietary changes, epithelialization (PEHI score), and color match were assessed over a 2-month follow-up.

The findings are expected to provide insights into whether i-PRF-enhanced chitosan offers superior healing outcomes and greater patient comfort compared to conventional methods.

Conditions

  • Free Gingival Graft
  • Wound Healing
  • i-PRF
  • Chitosan

Interventions

PROCEDURE

free gingival graft + gelatin sponge

Free gingival graft surgery and application of gelatin sponge to the palatal wound

PROCEDURE

free gingival graft + chitosan

free gingival graft surgery and application of chitosan to the palatal wound

PROCEDURE

free gingival graft + chitosan and i-PRF

free gingival graft surgery and application of chitosan and i-PRF to the palatal wound

Sponsors & Collaborators

  • Cukurova University

    collaborator OTHER

  • Biruni University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-07-12
Primary Completion
2025-12-10
Completion
2025-12-10

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07072546 on ClinicalTrials.gov