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Accuracy of 3D Electrical Impedance Tomography for Assessing Lung Ventilation

NCT07756086 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2026-08-10

No results posted yet for this study

Summary

This prospective observational study will evaluate how accurately three-dimensional electrical impedance tomography (3D-EIT) measures the distribution of air in the lungs during breathing when compared with four-dimensional computed tomography (4D-CT).

3D-EIT is a noninvasive, radiation-free imaging method that measures changes in electrical impedance across the chest and can provide continuous information about regional lung ventilation. In this study, 4D-CT will be used as the reference method because it can provide detailed images of changes in the lungs throughout the breathing cycle.

Approximately 50 adults, including healthy volunteers and hospitalized patients who are able to undergo both examinations, will be enrolled at a single center. EIT and CT data will be collected at the same time during stable breathing. Researchers will compare the two methods to determine how closely their measurements of ventilation in different lung regions agree. The study will also explore whether EIT can detect changes in regional ventilation under different breathing conditions.

The study will not use the research EIT results to make clinical treatment decisions. The findings may support the future use of EIT as a noninvasive, radiation-free method for monitoring regional lung ventilation.

Conditions

  • Pulmonary Ventilation

Interventions

DEVICE

Three-Dimensional Electrical Impedance Tomography

Regional lung ventilation data will be collected using a chest electrical impedance tomography system (V200-S). Electrical impedance changes in the chest will be measured continuously and reconstructed to assess three-dimensional regional ventilation distribution. EIT data will be acquired synchronously with dynamic computed tomography data and will be used for research analysis only. The research EIT results will not directly guide clinical treatment decisions.

DIAGNOSTIC_TEST

Dynamic Chest Computed Tomography

Dynamic chest computed tomography data will be acquired using an X-ray computed tomography system (uCT 610 Sim) during one or more breathing cycles. The images will be reconstructed and analyzed to quantify changes in regional lung air volume and ventilation distribution. The 4D-CT measurements will serve as the reference method for comparison with 3D-EIT measurements.

Sponsors & Collaborators

  • Shanghai Zhongshan Hospital

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-09-01
Primary Completion
2026-12-31
Completion
2027-07-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07756086 on ClinicalTrials.gov