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Electrical Impedance Tomography-derived Flow Index During Spontaneous Breathing Trial Stratifies the Risk of Reintubation Within 48 h After Extubation

NCT06876792 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2026-04-23

No results posted yet for this study

Summary

Accurate prediction of readiness to liberate patients from mechanical ventilation remains challenging. Conventional indices such as the rapid shallow breathing index (RSBI) and maximal inspiratory pressure (MIP) often miss early signs of injurious breathing patterns or regional ventilation asynchrony that can lead to extubation failure. Electrical impedance tomography (EIT) provides continuous, non-invasive imaging of regional lung ventilation. We developed a novel EIT-derived Flow Index (FI) which integrates the magnitude of inspiratory effort with the temporal synchrony of lung filling. This prospective, multicenter observational study aimed to (1) validate the predictive value of FI during spontaneous breathing trials (SBT) compared with conventional weaning indices, and (2) compare the predictive ability of EFI with traditional weaning indices(RSBI,MIP,P0.1).

Conditions

  • Acute Respiratory Failure
  • Ventilator Weaning Assessment

Interventions

DEVICE

electrical impedance tomography

Respiratory drive assessed by flow index measured by electrical impedance tomography.

Sponsors & Collaborators

  • Fujian Provincial Hospital

    collaborator OTHER

  • Peking Union Medical College Hospital

    collaborator OTHER

  • Ruijin Hospital

    lead OTHER

Principal Investigators

  • Hongping Qu · Department of Critical Care Medicine，Ruijin Hospital，Shanghai Jiao Tong University School of Medicine

  • Jialin Liu · Department of Critical Care Medicine，Ruijin Hospital，Shanghai Jiao Tong University School of Medicine

  • rui zhang · Department of Critical Care Medicine，Ruijin Hospital，Shanghai Jiao Tong University School of Medicine

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-12-01
Primary Completion
2025-12-31
Completion
2025-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06876792 on ClinicalTrials.gov