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Comparison of Post-operative Pain and Levels of MMP -9 Following Root Canal Irrigation With Sodium Hypochlorite Versus Cold Atmospheric Plasma in Patient With Necrotic Single Rooted Teeth: Randomized Clinical Trial

NCT07747753 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-08-05

No results posted yet for this study

Summary

The goal of this clinical trial is to compare the effect of cold atmospheric plasma versus sodium hypochlorite as irrigating solutions in necrotic single rooted teeth. The main questions it aims to answer are:

* Does the use of sodium hypochlorite solution or cold atmospheric plasma as root canal irrigant will have the same effect on the level of postoperative pain in necrotic single rooted teeth?
* Does the use of sodium hypochlorite solution or cold atmospheric plasma as root canal irrigant will have the same effect on the level of MMP -9 in necrotic single rooted teeth? Researchers will compare cold atmospheric plasma to sodium hypochlorite solution as root canal irrigant to see if cold atmospheric plasma works to have the same effect on the level of postoperative pain and levels of MMP -9 in necrotic single rooted teeth.

Participants will:

* be asked to rate their pain level according to the given instructions and will be asked to return for follow up after 2 days to hand the pain scale chart.
* be instructed to call the operator and will be permitted to take Ibuprofen 400 mg not more than 6 hours apart and to record their tablet intake within 48 hours postoperatively, in case of severe or persistent pain.
* be referred to the fixed prosthodontics department for final restoration.

Conditions

  • Necrotic Pulp

Interventions

OTHER

Application of cold atmospheric plasma

root canal disinfection protocol

Sponsors & Collaborators

  • Ahmed Hesham Abdelmohaimen Rezk

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-08-31
Primary Completion
2027-01-31
Completion
2027-03-31

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07747753 on ClinicalTrials.gov