Gingival Graft vs T-PRF in Papilla Defects

Summary

Objective: Titanium-prepared platelet-rich fibrin (T-PRF) has emerged as a promising biomaterial in periodontal regenerative procedures. The aim of this study will be to compare the clinical effectiveness of de-epithelialized gingival grafts (DGG) and T-PRF in the reconstruction of deficient interdental papillae using the tunnel technique.

Methods: A total of 34 patients presenting with 115 Class I and II interdental papilla defects will be enrolled in this study. Interdental papilla reconstruction will be performed using the tunnel technique in combination with either DGG or T-PRF. Demographic characteristics (age and sex), dentogingival variables (tooth shape, papilla location, jaw type, and papilla loss classification), and clinical parameters will be recorded. Clinical assessments will include probing depth (PD), gingival index (GI), plaque index (PI), gingival thickness (GT), keratinized tissue height (KTH), black triangle width (BTW), black triangle height (BTH), papilla fill percentage (%PF), and black triangle area (BTA). All clinical parameters will be assessed at baseline and at 1, 3, and 6 months following surgery.

Conditions

• Papilla Reconstruction

Interventions

PROCEDURE

De-epithelialized gingival graft

Papilla reconstruction was performed using the tunnel technique. Sulcular and horizontal incisions on the alveolar mucosa were made with a No. 15c scalpel, extending to the mid-buccal regions of the adjacent teeth. A partial-thickness tunnel flap was prepared using specialized tunneling instruments, with careful preservation of papillary integrity. Additional sulcular incisions were made on the palatal side, and the tunnel was extended beneath the carefully elevated palatal flap. De-epithelialized gingival graft material was inserted from the palatal aspect using a leader suture and guided through the tunnel to exit via the horizontal incision. It was then positioned and stabilized beneath the papillary tissue. Finally, suspension sutures were used to coronally advance the flap, which was secured to preoperatively prepared provisional composite splints to ensure tension-free closure.

PROCEDURE

Titanium-prepared Platelet-Rich Fibrin

Papilla reconstruction was performed using the tunnel technique. Sulcular and horizontal incisions on the alveolar mucosa were made with a No. 15c scalpel, extending to the mid-buccal regions of the adjacent teeth. A partial-thickness tunnel flap was prepared using specialized tunneling instruments, with careful preservation of papillary integrity. Additional sulcular incisions were made on the palatal side, and the tunnel was extended beneath the carefully elevated palatal flap. A Titanium-Prepared Platelet-Rich Fibrin (T-PRF) graft was introduced from the palatal aspect using a leader suture and guided through the tunnel to exit via the horizontal incision. The graft was positioned and stabilized beneath the papillary tissue. Finally, suspension sutures were used to coronally advance the flap, which was secured to preoperatively prepared provisional composite splints to ensure tension-free closure.

Sponsors & Collaborators

• Pamukkale University

  lead OTHER

Principal Investigators

• Makbule CAN, Res. asst. · Pamukkale University Faculty of Dentistry, Denizli, Turkey

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

25 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-11-15

Primary Completion

2023-02-14

Completion

2024-03-14

Countries

• Turkey (Türkiye)

Study Locations