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Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Pregnant Women With Hypertensive Disorders of Pregnancy

NCT07728656 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2026-07-27

No results posted yet for this study

Summary

Hypertensive disorders of pregnancy are associated with endothelial dysfunction and increased maternal and fetal morbidity. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation; however, their relationship with blood pressure and endothelial function during pregnancy remains incompletely understood. This observational case-control study aims to compare circulating EEV concentrations between normotensive pregnant women and pregnant women with hypertensive disorders of pregnancy. The study will also investigate the associations between EEV levels, blood pressure, microvascular endothelial function assessed by laser Doppler flowmetry, and circulating biomarkers of endothelial activation. The findings may improve understanding of endothelial injury during pregnancy and support the development of non-invasive biomarkers for early detection and monitoring of hypertensive disorders of pregnancy.

Conditions

  • Hypertensive Disorder of Pregnancy
  • Gestational Hypertension
  • Preeclampsia

Sponsors & Collaborators

  • Osijek University Hospital

    collaborator OTHER

  • Josip Juraj Strossmayer University of Osijek

    lead OTHER

Principal Investigators

  • Ana Stupin, MD, PhD · Faculty of Medicine Osijek, Josip Juraj Strossmayer of Osijek

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-04-01
Primary Completion
2029-04-30
Completion
2029-09-30

Countries

  • Croatia

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07728656 on ClinicalTrials.gov