RePer-AGE: Reorganization of Visuo-cognitive Functions Based on Peripheral Vision With Aging

Summary

The RePer-AGE study investigates how central and peripheral vision contribute to visual recognition and how these mechanisms change with normal aging. The study is based on the hypothesis that peripheral vision provides rapid global information that supports visual recognition through predictive mechanisms. Healthy young adults (18-30 years) and older adults (60-85 years) will undergo visual psychophysical testing, ophthalmological examinations, and, for a subset of participants, functional magnetic resonance imaging (fMRI). The results are expected to improve our understanding of age-related changes in visuo-cognitive functions and provide reference data for future studies on age-related visual disorders.

Conditions

• Aging
• Visual Perception
• Cognition

Interventions

BEHAVIORAL

Psychophysical visual recognition tasks

Computerized visual recognition tasks assessing the respective contributions of central and peripheral vision to scene recognition and predictive visual processing.

DIAGNOSTIC_TEST

Ophthalmological assessment

Ophthalmological examinations including retinal sensitivity (Humphrey automated perimetry) and low-luminance visual acuity.

DIAGNOSTIC_TEST

Functional magnetic resonance imaging (fMRI)

Functional MRI performed during psychophysical visual recognition tasks to assess brain activity associated with visual recognition and predictive visual processing.

Sponsors & Collaborators

• Centre National de la Recherche Scientifique, France

  collaborator OTHER

• University Grenoble Alps

  collaborator OTHER

• National Research Agency, France

  collaborator OTHER

• University Hospital, Grenoble

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

85 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2026-09-01

Primary Completion

2030-03-31

Completion

2030-09-30

Countries

• France

Study Locations