Brain Injury and Cognitive Function

Summary

The objective of this exploratory study is to elucidate the underlying cerebral mechanisms of cognitive deficits. To achieve this, the investigator will apply functional brain imaging techniques to patients suffering from cognitive deficits due to cerebral lesions.

The investigator will employ a "single-case" approach, suitable for studying rare behavioral profiles such as acquired reading disorders (alexia) or visual perception impairments (agnosia). If necessary, the investigator will use multiple non-invasive imaging methods in the same patients, including:

1. Magnetic Resonance Imaging (structural and functional), renowned for its spatial resolution and the diverse information it provides, and
2. Electrophysiological methods (MEG and EEG), notable for their temporal resolution.

The employed stimuli will consist of visual or auditory presentations of verbal material (words, sentences, numbers, etc.), potentially combined with the collection of simple vocal or motor responses (button presses).

The results will be interpreted by integrating the neuropsychological analysis of the deficit and the lesion topography.

Importantly, following the methodology of single-case neuropsychology, the stimulation protocols will be modulated and adapted to each individual case. Consequently, parallel data should be collected from healthy control subjects whenever necessary.

For protocol development, the investigator will also collect purely behavioral data, without brain imaging, from groups of control subjects.

Conditions

• Cerebral Lesion
• Cognitive Deficit Following Brain Lesions

Interventions

OTHER

imaging

Brain activation is demonstrated by measuring signal changes in brain regions. Activations will be determined by comparison between conditions and in relation to periods of rest

OTHER

Evoked Potentials

EEG signals, referenced to the right mastoid, were digitised at 125 Hz with an elliptical low-pass input filter at 49 Hz

OTHER

MEG

MEG signals reflect changes in magnetic field evoked by changes in neuronal activity

BEHAVIORAL

Behavioural tests

Behavioural tests will be evaluated.

Sponsors & Collaborators

• Institut National de la Santé Et de la Recherche Médicale, France

  lead OTHER_GOV

Study Design

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2014-02-05

Primary Completion

2027-02-05

Completion

2027-02-05

Countries

• France

Study Locations