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Brain Correlates of Visual Processing of Emotional Scenes in ACTion and EMOtional Judgments During Normal VIeillissement

NCT03969043 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2025-12-22

No results posted yet for this study

Summary

It is accepted that emotional events engage more attention and are detected and identified faster than neutral events. The same is true of negative events with regard to positive events. At the cerebral level, this facilitation results in greater activation of brain regions involved in visual and emotional processing. In normal aging, the preference for the negative stimuli (named negativity bias) tends to disappear and, sometimes, to shifts towards a preference for positive stimuli compared to both the negative and neutral stimuli (positivity bias). Most studies have assessed the age effect on emotional processing using tasks which require the identification of a personal emotional experience or the emotions of others.

Although many studies suggest a strong link between emotion and action, relatively little is known about the age effect on emotional processing when the task requires the identification of a tendency to action (i.e. preparation of the individual to react and direction of action - example: fear prepares to avoid danger).

ACTEMOVI project aims to identify the brain bases and neural networks involved in the processing of emotional visual information in normal aging when performing emotional appraisal and action-oriented tasks, through a functional MRI study.

Conditions

  • Aging

Interventions

OTHER

MRI

The MRI examination will consist of a series of acquisition scans: * Scanning Scan: for positioning the functional volume of interest. * Task Scans: for exploring cerebral activation in emotional and action appraisal tasks during viewing high and low arousal stimuli and a localizer task ". * Anatomical MRI: for analyzing the functional images, and measuring volumes of gray and white substances. * Resting state functional scan: for exploring cerebral activation during a rest activity. * Diffusion Tension Imaging: for measuring structural connectivity. * Perfusion imaging: scan for ensuring good perfusion conditions All functional acquisitions will be performed in multi-slices in echoplanar mode using gradient echo sequences allowing the exploitation of the BOLD contrast.

Sponsors & Collaborators

  • Laboratoire de Psychologie et NeuroCognition

    collaborator OTHER

  • University Hospital, Grenoble

    lead OTHER

Principal Investigators

  • Monica BACIU · Grenoble Alpes University Hospital

  • Aurélie Campagne · University Grenoble Alps

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-05-10
Primary Completion
2021-12-03
Completion
2021-12-03

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03969043 on ClinicalTrials.gov