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Clinicopathological Predictors of Recurrence in Papillary Thyroid Carcinoma

NCT07695974 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1113

Last updated 2026-07-10

No results posted yet for this study

Summary

The goal of this observational study is to identify demographic and clinicopathological factors associated with disease recurrence in adults with histologically confirmed papillary thyroid carcinoma (PTC) who achieved an initial disease-free status after primary treatment.

The main questions it aims to answer are:

Which demographic and clinicopathological characteristics are associated with an increased risk of PTC recurrence?

Researchers will compare patients who developed biochemical or structural recurrence with those who remained recurrence-free to assess the prognostic role of age, sex, tumor size, histological subtype, vascular invasion, capsular invasion, gross invasion of the prethyroid strap muscles, concomitant thyroiditis, multifocality, lymph-node status, and pathological stage.

As this is a retrospective study, participants will not undergo any study-specific intervention or additional procedure. Researchers will review existing demographic, surgical, pathological, treatment, and follow-up data from a prospectively maintained institutional database. Follow-up data include serial serum thyroglobulin measurements, neck ultrasonography, recurrence, and disease-specific mortality.

Conditions

  • Papillary Thyroid Carcinoma
  • Recurrence Free Survival

Sponsors & Collaborators

  • University of Roma La Sapienza

    lead OTHER

Principal Investigators

  • Eleonora Lori, MD · University of Roma La Sapienza

  • Salvatore Sorrenti, MD, PhD · University of Roma La Sapienza

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2000-01-07
Primary Completion
2018-08-31
Completion
2024-01-15

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07695974 on ClinicalTrials.gov