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MOUTHRİNSES AND PALATAL DONOR SİTE HEALİNG AFTER FREE GİNGİVAL GRAFT

NCT07689695 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 54

Last updated 2026-07-08

No results posted yet for this study

Summary

This single-blind randomized controlled clinical trial aimed to compare the effects of hypochlorous acid, hyaluronic acid, and chlorhexidine mouthrinses on palatal donor site healing following free gingival graft surgery. Fifty-four patients requiring free gingival graft surgery were randomly assigned to one of three mouthrinse groups. Clinical wound healing, wound dimensions, epithelialization, tissue consistency, bleeding control, and postoperative pain were evaluated during a 28-day follow-up period. The findings of this study may contribute to the identification of an effective postoperative mouthrinse for improving palatal donor site healing and patient comfort.

Conditions

  • Palatal Donor Site Wound Healing
  • Periodontal Plastic Surgery

Interventions

DRUG

Hypochlorous Acid

Commercially available hypochlorous acid mouthrinse (Crystalin®, NHP İlaç San. ve Tic. A.Ş., Ankara, Türkiye). Participants rinsed with 15 mL for 60 seconds three times daily for 14 days beginning 24 hours after free gingival graft surgery.

DRUG

Hyaluronic Acid (HA)

Commercially available hyaluronic acid mouthrinse (Gengigel®, Ricerfarma, Milan, Italy). Participants rinsed with 15 mL for 60 seconds three times daily for 14 days beginning 24 hours after free gingival graft surgery.

DRUG

Chlorhexidine gluconate 0.2%

Commercially available 0.2% chlorhexidine gluconate mouthrinse (Kloroben®, Drogsan, Ankara, Türkiye). Participants rinsed with 15 mL for 60 seconds three times daily for 14 days beginning 24 hours after free gingival graft surgery.

Sponsors & Collaborators

  • Yuzuncu Yil University

    lead OTHER

Principal Investigators

  • Hacer Şahin Aydınyurt, DDS, PhD · Van Yuzuncu Yil University Faculty of Dentistry

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-06-20
Primary Completion
2021-07-07
Completion
2021-07-07

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07689695 on ClinicalTrials.gov