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Comparison of the Effectiveness of Hypochlorous Acid and Chlorhexidine as a Post-surgical Antimicrobial Agent

NCT05952921 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 32

Last updated 2023-07-19

No results posted yet for this study

Summary

The aim of the study is to evaluate the effectiveness of Hypochlorous Acid and Chlorhexidine as postsurgical antimicrobial agents in the treatment of severe chronic periodontal disease. The selected patients will be randomly divided into two groups of 16 each. Subjects in group I will undergo scaling and surgical root planing and will use mouthrinse with 0.05% HOCl for 7 days, after this they will mouthwash with 0.025% HOCl until day 21 and Subjects in group II will undergo scaling and surgical root planing followed by a rinse with CHX 0.2% for 7 days, after this they will mouthwash with 0.12% CHX until day 21. Null Hypothesis: There are no significant differences between hypochlorous acid and chlorhexidine in reducing plaque formation at 7, 21 and 90 days of evaluation.

There are no significant differences between HOCl and CHX in the elimination or reduction of periodontopathogenic microorganisms at 7, 21 and 90 days. Alternative hypotheses: There are significant differences between hypochlorous acid and chlorhexidine in reducing plaque formation at 7, 21 and 90 days of evaluation. There are significant differences between HOCl and CHX in the elimination or reduction of periodontopathogenic microorganisms at 7, 21 and 90 days.

Conditions

  • Periodontal Diseases
  • Chronic Periodontitis
  • Microbial Colonization

Interventions

OTHER

Mouthwash

Concentration rinse with 0.05% HOCl

OTHER

Chlorhexidine

A high concentration of 0.2% CHX (7 days), followed by 0.012% CHX (14 days).

Sponsors & Collaborators

  • Universidad El Bosque, Bogotá

    lead OTHER

Principal Investigators

  • Julio Plata, DDS MSc · Universidad El Bosque

  • Gloria Lafaurie, DDS MSc · Unit of Basic Oral Investigation (UIBO) - Universidad El Bosque

  • David Díaz-Báez, DDS MSc · Unit of Basic Oral Investigation (UIBO) - Universidad El Bosque

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-07-10
Primary Completion
2019-12-01
Completion
2019-12-15

Countries

  • Colombia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05952921 on ClinicalTrials.gov