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Comparative Efficacy of Different Dentin Occluding Toothpaste Technologies

NCT07664592 · Status: RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 132

Last updated 2026-08-07

No results posted yet for this study

Summary

The purpose of this clinical study is to evaluate and compare how well three different types of toothpaste technologies work to relieve tooth sensitivity, also known as dentin hypersensitivity. The study asks the question: How effective are toothpastes containing 8% Arginine, 8% Arginine with Zinc Phosphate, or 5% Calcium Sodium Phosphosilicate (CSPS) at providing immediate and short-term relief for people suffering from sensitive teeth?

Conditions

  • Dentinal Sensitivity
  • Dentinal Hypersensitivity

Interventions

DRUG

8% arginine + Zinc toothpaste

A commercially available fluoride toothpaste containing 8% arginine + Zinc Phosphate

DRUG

5% Calcium Sodium Phosphosilicate toothpaste

A commercially available fluoride toothpaste containing 5% Calcium Sodium Phosphosilicate (CSPS)

DRUG

8% arginine toothpaste

A commercially available fluoride toothpaste containing 8% arginine

Sponsors & Collaborators

  • Federal University of Rio Grande do Sul

    collaborator OTHER

  • Colgate Palmolive

    lead INDUSTRY

Principal Investigators

  • Cassiano K Rosing, PhD · Federal University of Rio Grande do Sul

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-06-29
Primary Completion
2026-09-30
Completion
2026-09-30

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07664592 on ClinicalTrials.gov