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Perforated Appendicitis and Postoperative Antibiotics Pilot Trial

NCT07656636 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2026-06-18

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if not giving antibiotics is as effective as giving antibiotics after surgery for patients who have surgery for a perforated (burst) appendix. This pilot study will also help determine whether a larger, multi-centre study can be successfully conducted. The main questions it aims to answer are:

* Do patients who do not receive antibiotics after surgery have similar rates of infection after surgery as patients who do?
* Is it feasible to enroll and randomize patients and collect complete health data for a larger multi-centre study?

Researchers will compare patients who do not receive antibiotics after surgery to patients who do to see whether avoiding antibiotics is as effective as using antibiotics for preventing infections after surgery.

Participants will:

* Be randomly assigned to either receive or not receive antibiotics after surgery for their perforated (burst) appendix.
* Be contacted 30 and 90 days after surgery to check for infections and other health outcomes.

Conditions

  • Perforated Appendicitis

Interventions

DRUG

Postoperative antibiotico-prophylaxis

Patients receive oral antibiotics following surgery for perforated appendicitis. The dose, duration, and type are at the discretion of the treating physician.

OTHER

No postoperative antibiotics

Patients do not receive antibiotics following surgery for perforated appendicitis.

Sponsors & Collaborators

  • Sunnybrook Health Sciences Centre

    collaborator OTHER

  • London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-08-01
Primary Completion
2027-09-01
Completion
2027-11-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07656636 on ClinicalTrials.gov