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Comparison of Oral Antibiotics For Bone Infections of the Leg and Foot

NCT07266753 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 1418

Last updated 2026-03-27

No results posted yet for this study

Summary

The goal of this clinical trial is to compare different classes of oral antibiotics (beta-lactam and non-beta-lactam antibiotics) for the treatment of bone infections of the leg and foot. The hypothesis is that oral beta-lactam antibiotics work as well as oral non-beta-lactam antibiotics to treat these infections. The first step is to assess whether it is possible to perform the trial by determining whether participants can be recruited and followed successfully. If the trial is proven to be possible, it will be expanded to ensure an answer to whether the two antibiotic classes work as well for the treatment of bone infections of the leg and foot.

Conditions

  • Osteomyelitis of Lower Extremities
  • Osteomyelitis - Foot
  • Osteomyelitis of the Foot

Interventions

DRUG

Oral Beta-Lactam Antibiotic

Participants in this arm are randomized to receive an oral antibiotic from the beta-lactam class (e.g., penicillins or cephalosporins) for the treatment of lower extremity osteomyelitis.

DRUG

Oral Non-Beta-Lactam Antibiotic

Participants in this arm are randomized to receive an oral antibiotic from the non-beta-lactam class (e.g., fluoroquinolones, lincosamides, sulfonamides) for the treatment of lower extremity osteomyelitis.

Sponsors & Collaborators

  • University Health Network, Toronto

    collaborator OTHER

  • The Ottawa Hospital Research Institute

    collaborator UNKNOWN

  • Michael Garron Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-02-26
Primary Completion
2031-12-31
Completion
2033-12-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07266753 on ClinicalTrials.gov