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Virtual Reality-Assisted Exercise in Pediatric Hematopoietic Stem Cell Transplantation

NCT07653880 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 38

Last updated 2026-06-17

No results posted yet for this study

Summary

This randomized controlled, single-blind clinical trial investigates whether virtual reality (VR)-assisted, video game-based exercise training, added to a conventional pulmonary physiotherapy and rehabilitation program, improves functional level, respiratory parameters, and physical fitness in pediatric patients (5-18 years) following hematopoietic stem cell transplantation (HSCT). Participants attended 24 supervised, face-to-face exercise sessions over 8 weeks (3×/week) under physiotherapist supervision. The Experimental Group received game-based exercise using the Nintendo Wii Fit U platform with the Wii Balance Board and the Breathing Labs Breathing Games software (Slovenia) in addition to the conventional program. Outcomes included the Modified Alpha-Fit Pediatric Test Battery (vertical jump, 6-minute walk test, sit-and-reach, flamingo balance), upper-extremity isometric muscle strength (handheld dynamometry) and handgrip strength (Jamar), pulmonary function tests, maximal inspiratory and expiratory mouth pressures, accessory respiratory muscle architecture by myotonometry (MyotonPro: sternocleidomastoid, upper trapezius, pectoralis major), and ultrasound assessment of pleural thickness, diaphragm thickness, and diaphragm excursion.

Conditions

  • Hematopoietic Stem Cell Transplantation (HSCT)
  • Pediatric Physiotherapy
  • Pulmonary Rehabilitation
  • Physiotherapy and Rehabilitation
  • Cancer

Interventions

OTHER

EXERCISE TRAINING WITH OR WITHOUT MEDICATION

Physiotherapist-led pulmonary rehabilitation program (24 sessions; 3×/week × 8 weeks). Components: diaphragmatic breathing, thoracic expansion exercises, incentive spirometry, postural drainage with percussion, cough techniques, breathing control, and range-of-motion exercises. Intensity titrated by Modified Borg Scale (target 4-6).

OTHER

EXERCISE TRAINING WITH OR WITHOUT MEDICATION

Game-based exercise sessions delivered concurrently with the conventional program. Breathing Labs games (Balloon, Plane, Wolf, Flowers, Pluto) progressed in difficulty between weeks 1-4 and 5-8. Wii Fit U weight-shifting games (Balance Bubble, Table Tilt, Perfect 10, Super Hula Hoop) and stepping/squatting games (Obstacle Course, Advanced Obstacle Course, Ski Jump, Basic Step) were played 4 per session for 5 minutes each on the Wii Balance Board, with or without chair-back support based on tolerance. Total 24 sessions over 8 weeks.

Sponsors & Collaborators

  • Health Institutes of Turkey

    collaborator OTHER_GOV

  • Istinye University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
5 Years
Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-01-16
Primary Completion
2025-08-30
Completion
2025-09-15

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07653880 on ClinicalTrials.gov