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The Effects of Strength Training on Muscle Mass and Mental Health in Adults Taking Obesity Medication

NCT07652333 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2026-06-24

No results posted yet for this study

Summary

The purpose of this study is to examine the effects of resistance exercise, such as weightlifting, on retention of muscle mass and mental health in individuals taking GLP-1 RAs (an obesity medication). Resistance exercise is focused on increasing the strength of participants' muscles, such as how much participant can lift.

•The duration of this study is 3 months. This includes:

* Orientation session to explain study protocol, exercise program, and complete questionnaire about participants' medical history and lifestyle.
* Two health assessments at baseline and at 3 months. These assessments include body composition, resting blood pressure, cardiovascular function, and muscular strength. Both the resistance exercise group and the control group will complete assessments at baseline and again at 3 months. After the 3-month period, individuals in the control group may choose to participate in the exercise training and complete the optional 6-month assessments.
* Personalized resistance exercise sessions for 60 minutes per session, twice per week, for 3 months.

Conditions

  • Muscle Composition
  • Obesity
  • Quality of Life (QOL)

Interventions

BEHAVIORAL

Resistance Exercise

60 min/session, all for 2 sessions/week for 12 weeks

DRUG

GLP-1 RAs

Participants will take GLP-1 RAs for 12 weeks

Sponsors & Collaborators

Principal Investigators

  • Jiyeon Yoon, M.S. · University of Pittsburgh

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-05-25
Primary Completion
2027-04-30
Completion
2027-05-31

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07652333 on ClinicalTrials.gov