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Volume Removal Intolerance During Net Ultrafiltration in Acute Kidney Injury Patients

NCT07643597 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 128

Last updated 2026-07-08

No results posted yet for this study

Summary

Acute kidney injury (AKI) is common in critically ill patients and is frequently associated with fluid overload, which can worsen clinical outcomes. Continuous renal replacement therapy (CRRT) allows fluid removal through net ultrafiltration (UFNET), but some patients develop hemodynamic instability or signs of poor tissue perfusion during this process.

The purpose of this prospective observational study is to evaluate tolerance to net ultrafiltration in critically ill patients with AKI receiving CRRT. The study will assess clinical, hemodynamic, ultrasound, perfusion, and biochemical parameters before and during fluid removal to identify factors associated with ultrafiltration intolerance.

The investigators hypothesize that alterations in hemodynamic, perfusion, and congestion-related parameters can identify patients at increased risk of ultrafiltration intolerance before the development of overt hypotension. The results may help improve individualized fluid removal strategies and optimize the safety of CRRT in critically ill patients.

Conditions

  • Acute Kidney Injury
  • Fluid Overload
  • Fluid Overload in Dialysis Patients
  • Critical Illness
  • Renal Replacement Therapy for Acute Kidney Injury in ICU

Sponsors & Collaborators

  • Hospital Las Higueras

    lead OTHER

Principal Investigators

  • Gonzalo Ramírez-Guerrero, MD · Hospital Las Higueras de Talcahuano

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-07-06
Primary Completion
2027-12-01
Completion
2027-12-01

Countries

  • Brazil
  • Chile
  • Colombia
  • Ecuador
  • Italy
  • Mexico
  • Peru

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07643597 on ClinicalTrials.gov