REVERSE-AKI Randomized Controlled Pilot Trial

Summary

Observational studies among patients with acute kidney injury (AKI) have shown an association with fluid accumulation and increased mortality. Trials among other subgroups of critically ill patients have demonstrated that restricting fluid input after the initial resuscitation appears safe.

The objective if this study is to determine whether a fluid restrictive treatment regimen will lead to a lower cumulative fluid balance at 72 hours from randomization in critically ill patients with AKI and whether this approach is safe and feasible.

Conditions

• Acute Kidney Injury
• Critical Illness

Interventions

OTHER

Restrictive fluid management

Daily fluid input is restricted to drugs and nutrition. Fluid boluses and blood products can be given if clinically indicated. Matching fluid output to fluid input whenever possible using diuretics if needed, and additionally, if clinically necessary and plausible, commencing renal replacement therapy. If renal replacement therapy is not deemed clinically desirable, acceptance of a less than targeted fluid balance.

Sponsors & Collaborators

• Austin Hospital, Melbourne Australia

  collaborator OTHER

• Guy's and St Thomas' NHS Foundation Trust

  collaborator OTHER

• University Hospital, Ghent

  collaborator OTHER

• Medical University Innsbruck

  collaborator OTHER

• University of Lausanne Hospitals

  collaborator OTHER

• Helsinki University Central Hospital

  lead OTHER

Principal Investigators

• Suvi Vaara, MD, PhD · Division of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

• Marlies Ostermann, MD, PhD · Department of Critical Care and Nephrology, King's College London, Guy's and St Thomas Hospital, Foundation Hospital, London

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-11-08

Primary Completion

2020-01-31

Completion

2020-04-30

Countries

• Australia
• Belgium
• Finland
• Switzerland
• United Kingdom

Study Locations