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The Role of Estradiol and Progesterone on Appetite Regulation and Energy Balance

NCT07620587 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-06-02

No results posted yet for this study

Summary

The goal of this study is to determine if estradiol and progesterone are involved in appetite regulation and energy balance. The study aims to complete a 13 day randomized controlled trial (RCT) where oral supplementation of estradiol only, progesterone only, a combination of each, or a placebo in young males will be provided. During the supplementation period, participants will complete two in-lab sessions where they will complete an acute bout of high-intensity interval training or a period of seated rest (completed on separate days by each participant) and have blood samples and perceptions of appetite measured taken over the course of the in-lab sessions. At the end of each session participants will consume an ad-libitum meal and participants will also track free-living energy intake and wear a thigh-worn accelerometer to measure energy expenditure for three days (day before, day of, and day after) each in-lab session.

Conditions

  • Energy Balance
  • Physiology - Regulation of Appetite and Food Intake

Interventions

DRUG

Placebo Comparator

See description of intervention arm.

DRUG

Estradiol Only

See description of intervention arm.

DRUG

Progesterone Only

See description of intervention arm.

DRUG

Estradiol and Progesterone Combination

See description of intervention arm.

Sponsors & Collaborators

  • Wilfrid Laurier University

    lead OTHER

Principal Investigators

  • Tom J Hazell, PhD · Wilfrid Laurier University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-06-01
Primary Completion
2028-08-31
Completion
2028-08-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07620587 on ClinicalTrials.gov