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Prevention of Obesity in Women Via Estradiol Regulation

NCT00687739 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 79

Last updated 2025-04-01

Study results available
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Summary

The purpose of this study is to evaluate potential mechanisms by which estradiol deficiency accelerates fat gain and abdominal fat accumulation in women.

Conditions

Interventions

DRUG

leuprolide acetate

3.75 mg for depot suspension delivered by monthly intramuscular injection for 5 months

DRUG

Estradiol Transdermal

0.075 mg patch per day for 5 months

BEHAVIORAL

progressive resistance exercise training

45 minute exercise sessions 4 times per week for 5 months

Sponsors & Collaborators

  • National Institute on Aging (NIA)

    collaborator NIH

  • University of Colorado, Denver

    lead OTHER

Principal Investigators

  • Wendy M Kohrt, PhD · University of Colorado, Denver

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
49 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-05-31
Primary Completion
2014-06-30
Completion
2014-06-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00687739 on ClinicalTrials.gov