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Potential Biomarkers and Pathogenic Mechanism for Reflux Aspiration-induced Lung Injury.

NCT06164639 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 28

Last updated 2025-07-30

No results posted yet for this study

Summary

There is limited research on aspiration pneumonia-induced ARDS (Acute Respiratory Distress Syndrome), and currently there is a lack of studies on corresponding biomarkers and pathogenic mechanisms. We hypothesize that pH and amylase in BAL (Bronchoalveolar Lavage) may serve as candidate biomarkers for inhalation-induced ARDS. Furthermore, we use EIT analysis to explore the pathological mechanisms of ARDS induced by AP and evaluate the clinical value of NO in improving hypoxemia.

Conditions

  • ARDS, Human
  • Aspiration Pneumonia

Interventions

BEHAVIORAL

aspiration

Based on whether the patient meets the diagnosis of aspiration pneumonia.

DIAGNOSTIC_TEST

bronchial alveolar fluid

Performing bronchoscopy.

DEVICE

EIT V/Q test

Local pulmonary ventilation and perfusion are measured by electrical impedance tomography (EIT). For perfusion imaging, 10 ml of 5% saline is injected as a central venous bolus. The matching of ventilation and perfusion reveals intrapulmonary shunting.

OTHER

Nitric oxide inhalation

According to the physician's judgment and the family members' consent, the patient is administered nitric oxide inhalation at a dosage of 20-30 parts per million (ppm).

Sponsors & Collaborators

  • Shanghai Zhongshan Hospital

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-11-28
Primary Completion
2025-11-28
Completion
2026-11-28

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06164639 on ClinicalTrials.gov