MedTrace Logo

Urinary Chloride and Sodium Changes and Residual Congestion in Acute Heart Failure

NCT07597512 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 223

Last updated 2026-05-22

No results posted yet for this study

Summary

The goal of this observational study is to learn how changes in urinary sodium and chloride levels relate to fluid overload and short-term outcomes in patients hospitalized with acute heart failure (AHF). The main questions it aims to answer are:

* Do changes over time in urinary sodium and chloride reflect how well excess fluid is being removed during hospitalization?
* Are these changes associated with residual congestion at discharge and with the risk of worsening heart failure or death after discharge?

Participants hospitalized for AHF and treated with intravenous diuretics as part of their usual care will have clinical assessments, blood and urine tests, and echocardiographic evaluations collected at several time points during their hospital stay. Researchers will also record clinical outcomes, including worsening heart failure or death, at 30 days and 3 months after discharge.

Conditions

Sponsors & Collaborators

  • Carlos III Health Institute

    collaborator OTHER_GOV

  • Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal

    lead OTHER

Principal Investigators

  • Pau Llàcer Iborra, MD PhD · Fundación para la Investigación Biomédica del Hospital Universitario Ramón y Cajal (FIBioHRC)

  • Luis Manzano Espinosa, MDPhD · Hospital Universitario Ramón y Cajal

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-05-31
Primary Completion
2028-12-31
Completion
2028-12-31

Countries

  • Spain

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07597512 on ClinicalTrials.gov