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Evaluating Residual Congestion at Discharge in Acute Heart Failure Patients

NCT06993220 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 500

Last updated 2025-07-18

No results posted yet for this study

Summary

Treatment of congestion is one of the main goals in patients hospitalized for acute heart failure. Nevertheless, current evidence shows that decongestion is often not achieved and that residual congestion at discharge is strongly associated with poor outcomes. While this association has been demonstrated, previous studies have primarily focused on single parameters of congestion (physical examination, biomarkers, or imaging features). The aim of the study is to assess residual congestion at discharge using a multiparametric approach and to compare the prognostic value of each evaluation strategy. Additionally, the analysis will be supported by artificial intelligence to develop a multiparametric prognostic algorithm that can provide an improved predictive model compared to standard statistical approaches.

Conditions

  • Acute Heart Failure (AHF)
  • Congestive Heart Failure(CHF)

Interventions

DIAGNOSTIC_TEST

Evaluation of residual congestion at discharge

Evaluation of residual congestion at discharge will be made using: * Clinical variables: composite congestion score calculated by summing the individual scores for orthopnoea, jugular venous distension and pedal oedema; * Imaging variables: non-invasive left ventricular filling pressure, number of LUS B lines and the presence of pleural effusion, Venous Excess UltraSound (VExUS) score; * Laboratory variables: hemoglobin and hematocrit, NT-proBNP, CA-125, ST2, troponin T, creatinine, AST, ALT, Na, K, urea, bilirubin, C-reactive protein.

Sponsors & Collaborators

  • Consorci Sanitari Integral

    lead OTHER

Principal Investigators

  • Giosafat Spitaleri, M.D. · Consorci Sanitari Integral

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-01-01
Primary Completion
2026-06-01
Completion
2027-01-01

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06993220 on ClinicalTrials.gov