Comparison of NeuroEXPLORER PET/CT Versus Standard-of-care PET/CT of the Head and Neck Region.

Summary

The goal of this clinical study is to compare the current standard-of-care PET/CT scanner with the new NeuroEXPLORER PET/CT, with the aim of demonstrating the added diagnostic value of the new scanner. As this is the first device of its kind in Europe, the study will also evaluate the safety and general feasibility of the NeuroEXPLORER system for head and neck PET studies.

Due to to its high resolution, the NeuroEXPLORER enables an accurate investigation of areas up to 20 times smaller than what can be visualized with standard clinical PET scanners, providing images with a very high level of detail. This scanner is specifically designed for imaging the brain, spinal cord, and neck region, to support the diagnosis and monitoring of neurological, psychiatric, and other disorders in the head and neck.

The main questions this study aims to answer are:

* Does the NeuroEXPLORER provide more detailed information with better diagnostic quality compared to standard clinical PET/CT scans for head and neck disorders?
* Is the NeuroEXPLORER system safe and effective in performing head and neck studies?

Participants will:

* receive clear information about the study, including its organization, possible risks, and potential benefits. Based on this, they will be able to give their informed consent by signing an informed consent form before the study begins.
* visit the clinic (UZ Leuven) once for two consecutive PET/CT scans: first the prescribed clinical scan, followed by a shorter scan with the NeuroEXPLORER.
* before the start of the regular PET/CT scan, have a small catheter placed in a blood vessel in the forearm. Through this, a tracer will be administered. A tracer is a small amount of slightly radioactive material that helps to produce images of processes inside the body. Depending on the tracer used, the PET/CT scan may start immediately or after a short waiting period.
* lie on their back on the scanner bed for 10 to 30 minutes during the clinical scan.
* after the clinical scan, undergo a 15-20 minute scan on the NeuroEXPLORER.
* leave the hospital after completing both scans.
* afterwards, be asked whether they experienced any discomfort during the study. In addition, they will receive a one-time follow-up phone call within a week after the scan to check if they experienced any discomfort in the days following the study.

Conditions

• Dementia
• Movement Disorders
• ALS - Amyotrophic Lateral Sclerosis
• Epilepsy
• Brain Tumors
• Pituitary Adenoma
• Large Vessel Vasculitis
• Head and Neck Tumors
• Parathyroid Adenomas
• Neuroblastoma
• PARKINSON DISEASE (Disorder)
• Lewy Body Dementia
• Alzheimer s Disease
• Fronto-temporal Dementia

Interventions

DEVICE

Standard-of-care PET/CT

This PET/CT is the routinely used clinical PET/CT scan

DEVICE

NeuroEXPLORER

This is the new ultra-high resolution PET/CT scan

Sponsors & Collaborators

• KU Leuven

  collaborator OTHER

• prof. dr. Koen Van Laere

  lead OTHER

Study Design

Allocation

NA

Purpose

DIAGNOSTIC

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

28 Days

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2025-09-30

Primary Completion

2030-08-31

Completion

2030-08-31

Countries

• Belgium

Study Locations