MedTrace Logo

Vascular Endothelial Inflammation and Health Status In INOCA (VISION-INOCA)

NCT07586241 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 250

Last updated 2026-05-14

No results posted yet for this study

Summary

The purpose of this study is to evaluate coronary artery and peripheral vein vascular endothelial profiles in patients with ischemia with non-obstructive coronary arteries (INOCA) who undergo coronary function testing (CFT). The aims are: (1) Evaluate coronary artery endothelial profiles and associations with coronary microvascular dysfunction (CMD) in INOCA. (2) Assess brachial vein endothelial cell profiles in patients with INOCA and associations with CMD, and (3) Characterize relationships between endothelial signatures and anginal symptoms, functional status, and physical activity at baseline and 1-year follow-up.

Conditions

  • Ischemia and Non-obstructive Coronary Arteries

Interventions

PROCEDURE

Invasive coronary angiography

Participant will undergo invasive coronary angiography as clinically indicated (standard of care).

PROCEDURE

Coronary Artery Endothelial Cell Sampling

Endothelial cells will be obtained from clinical coronary guidewires after retrieval from the guide catheter.

DEVICE

Fitbit

Wearable activity monitoring device that measures physical activity based on the number of steps per day. The device also tracks sleep efficiency (exploratory) through a proprietary algorithm, and other health metrics. Daily step count and heart rate are recorded on the wearable device.

DIAGNOSTIC_TEST

Invasive coronary function testing

Participants will undergo invasive coronary function testing as clinically indicated (standard of care).

Sponsors & Collaborators

Principal Investigators

  • Nathaniel Smilowitz, MD · NYU Langone Health

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-05-31
Primary Completion
2030-12-31
Completion
2031-03-01

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07586241 on ClinicalTrials.gov