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Exercise-induced Epigenetic Adaptations

NCT07582094 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2026-05-12

No results posted yet for this study

Summary

Among all patients, aged between 20 and 80 years old, with heart failure (HF) underwent guideline-directed medical therapy (GDMT) in a tertiary care hospital, 40 of them with stable clinical status greater than 4 weeks were sequentially enrolled in the study. Thery were further allocated into the high-intensity interval training (HIIT) and GDMT groups. The 20 HIIT participants underwent additional 36 sessions of exercise training with alternating 80% of peak oxygen consumption (VO2peak) and 40% of VO2peak for 30 mins, whereas the remaining 20 GDMT participants received regular medication treatement. Baseline clinical information was recorded. Cardiopulmonary exercise test (CPET), 2-D echocardiography, bioimpedance analysis, questionnaire for quality of life, serum b-type natriuretic peptide (BNP), circulating microRNA (miRNA) profile and serum metabolomics before intervention were assessed. Cardiomyocytes and/or cardiac fibroblasts were harvested in 10% patient serum for cell activities, western blot, and messenger RNA studies. All the above examinations were followed after completing the exercise training in HIIT participants and 3-4 months after initial visit in GDMT participants. Parametric anslysis was used to assess the differences of continuous parameters with normal distributions. Those without normal distributions were estimated with non-parametric analysis. 2x2 ANOVA was conducted to compare differences of the circulating miRNA between the two groups of participants before and after interventions. Non-continous parameters between the two groups were assessed by chi-square test.

Conditions

Interventions

BEHAVIORAL

high-intensity interval training

The participants underwent 36 sessions of alternating 3-min of 80% peak oxygen consumption (VO2peak) and 40% VO2peak for 30-min

Sponsors & Collaborators

  • Chang Gung Memorial Hospital

    lead OTHER

Principal Investigators

  • Chih-Chin Hsu, MD, PhD · Department of Physical Medicine and Rehabilitation, Keelung Chang Gung Memorial Hospital

Study Design

Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
DOUBLE
Model
SINGLE_GROUP

Eligibility

Min Age
20 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-08-01
Primary Completion
2022-07-31
Completion
2023-07-31

Countries

  • Taiwan

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07582094 on ClinicalTrials.gov