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A Study to Learn if a Medicine Called Itraconazole Changes How the Body Processes the Study Medicine PF-08642534 in Healthy Adults.

NCT07575945 · Status: NOT_YET_RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 14

Last updated 2026-05-08

No results posted yet for this study

Summary

The purpose of this study is to learn if a medicine called itraconazole changes how the body processes the study medicine (PF-08642534) in healthy adults.

This study is seeking healthy participants (men or women) who:

* are aged 18 to 65 years of age
* are confirmed to be healthy by their medical history and medical tests
* have body mass index (BMI) of 16 to 30 kilograms per meter squared
* have a total body weight of more than 50 kilograms.

Participants will receive single doses of the study medicine (PF-08642534) with and without itraconazole.

The total planned time of participation is about 12 weeks. The study consists of:

* a screening period of up to 28 days before taking study drug
* about 4 weeks of staying in the study clinic
* a follow-up contact that will occur 28 to 35 days after taking itraconazole the last time.

Conditions

  • Healthy Participant

Interventions

DRUG

PF-08642534

Participants will receive a single dose of PF-08642534

DRUG

Itraconazole

Participants will receive itraconazole once daily for 13 days (Day 12 to Day 24)

Sponsors & Collaborators

Principal Investigators

  • Pfizer CT.gov Call Center · Pfizer

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-05-05
Primary Completion
2026-06-26
Completion
2026-07-23
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07575945 on ClinicalTrials.gov