MedTrace Logo

Periodontal Disease in Rare Renal Disorders (PERIO-RA-RE)

NCT07575347 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2026-05-08

No results posted yet for this study

Summary

This study aims to evaluate the burden and phenotypic spectrum of periodontal disease in patients with rare kidney disorders (such as Alport syndrome, Fabry disease, and tuberous sclerosis complex) and systemic lupus erythematosus (SLE), compared with chronic kidney disease (CKD) controls and population controls.

This is a cross-sectional, case-control observational study. Participants will undergo a single structured evaluation including a full-mouth periodontal examination, a clinical questionnaire, and collection of relevant clinical and nephrological data.

The primary objective is to compare the prevalence of periodontitis across study groups. Secondary objectives include characterization of periodontal disease severity, prevalence of gingivitis and xerostomia, and identification of disease-specific oral phenotypes.

Exploratory analyses will assess associations between periodontal disease and clinical variables such as kidney function, proteinuria, and immunosuppressive exposure.

Conditions

Interventions

OTHER

Observational assessment

Non-interventional observational assessment including periodontal examination and clinical data collection.

Sponsors & Collaborators

  • Institutul Clinic Fundeni

    collaborator OTHER

  • Stefan Lujinschi

    lead OTHER

Principal Investigators

  • Gener Ismail, Professor, MD, PhD · Fundeni Clinical Institute

  • Bahtiar Ismail, MD, PhD · Emergency University Hospital Bucharest

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-05-04
Primary Completion
2027-12-31
Completion
2027-12-31

Countries

  • Romania

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07575347 on ClinicalTrials.gov