Deep Brain Stimulation in Parkinson's Disease: Motor and Functional Outcomes

Summary

Introduction: Parkinson's Disease (PD) is a progressive neurodegenerative condition characterized by classic motor symptoms, such as bradykinesia, rigidity, resting tremor, and postural instability, which directly compromise the mobility and autonomy of individuals with PD. Furthermore, non-motor manifestations, including autonomic, cognitive, and emotional changes, impact the quality of life of individuals with PD. Deep Brain Stimulation (DBS) surgery is a well-established treatment to assist in improving the primary motor symptoms of PD; however, literature is scarce in describing specific results regarding physiotherapeutic aspects, such as the motor symptoms that determine better quality of life and social participation for individuals with PD. Determining whether factors amenable to improvement prior to surgery-such as bradykinesia, muscle strength, and balance-are related to better motor and functional outcomes in individuals with PD post-DBS is of great importance to ensure a better result from the surgical intervention.

Objective: To compare motor outcomes (gait speed, balance, freezing of gait, fear of falling, muscle strength, functional capacity, and physical activity level) of individuals with PD after undergoing DBS, relative to the motor status previously observed in the preoperative period.

Methods: This is an uncontrolled clinical trial, with data collection conducted at the Neurovida private multidisciplinary clinic and the Hospital Santa Casa in Belo Horizonte. This study will be registered at www.clinicalTrials.gov and conducted according to the Consolidated Standards of Reporting Trials (CONSORT) recommendations. The present study will be submitted to the Research Ethics Committee of the Federal University of Minas Gerais (COEP) and will only commence after proper approval. All necessary consents for the development of the study have been obtained. The sample consists of individuals with idiopathic PD selected by a clinical neurologist specializing in movement disorders. The inclusion criteria for the present study are: having idiopathic PD diagnosed for more than five years, being under treatment with a neurologist specializing in movement disorders, and having an indication for DBS. Descriptive statistics and normality tests will be performed for all study variables. Selected variables will be compared in terms of mean difference between post- and pre-surgery measurements, considering a 95% CI. In all analyses, a significance level of α=0.05 will be considered, using the SPSS statistical package version 15.0 for Windows.

Conditions

• Parkinson Disease

Interventions

PROCEDURE

Deep Brain Stimulation

Deep Brain Stimulation (DBS) is a stereotactic surgical technique used for the control and management of motor complications arising from L-dopa treatment. DBS consists of neural modulation through implanted electrodes connected to a neurostimulator (SHARMA et al., 2020). The fundamental criterion for surgical indication is refractoriness to conservative treatment. Of the four cardinal manifestations presented, three are suitable for surgical treatment: tremor, rigidity, and bradykinesia. The levodopa challenge test allows for an approximate assessment of the improvement that can be achieved with surgery; the ideal candidate is one who is severely impaired in the 'off' state and presents motor complications related to levodopa treatment or refractory tremor (HAMANI et al., 2008; FONOFF, 2012).

Sponsors & Collaborators

• Federal University of Minas Gerais

  lead OTHER

Study Design

Allocation

NA

Purpose

TREATMENT

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-04-28

Primary Completion

2026-12-05

Completion

2026-12-05

Countries

• Brazil

Study Locations