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Pathways Mediating Impaired Postural Control in Parkinson's Disease

NCT06464029 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2025-05-08

No results posted yet for this study

Summary

The purpose of this project is to use transcranial magnetic stimulation (TMS) to explore the state of excitability of corticocortical and corticofugal (cortex to spinal cord, cortex to brainstem to spinal cord) pathways that project to muscles that control the legs and trunk in people with Parkinson's disease. The outcome variables will be further analyzed to understand their relationship to quantitative measures of postural instability and gait dysfunction. As such, the project can be classified as basic physiologic research. The protocol is not designed to determine if measures of corticocortical or corticofugal excitability can be used as a biomarker to predict disease progression.

Conditions

  • Parkinson Disease

Sponsors & Collaborators

Principal Investigators

  • Colum MacKinnon, MD · University of Minnesota

Eligibility

Min Age
45 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-06-01
Primary Completion
2027-06-10
Completion
2027-06-10

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06464029 on ClinicalTrials.gov