Telemedicine Self-examination of Speech and Memory for Rapid Detection of Cognitive Impairments Using Machine Learning Methods

Summary

Early cognitive disorders diagnosis is becoming increasingly important due to population aging. The most common causes include Alzheimer's disease and frontotemporal dementia. These diseases are also manifested by changes in speech. NLP allows us to identify and classify these changes. The project aims to develop a web application for self-assessment and automated detection of cognitive disorders from speech. The application will have a form of a dialogue system using machine learning methods. The novelty of this approach is the possibility of an efficient self-assessment of a wide spectrum of the Czech population from their homes and an automated evaluation of test results. Early detection can be followed by a more detailed diagnosis and adequate treatment.

Conditions

• Mild Cognitive Impairment (MCI)
• Dementia
• Mild Cognitive Impairment (MCI) Amnestic
• Frontotemporal Degeneration (FTD)
• Alzheimer Disease (AD)

Interventions

DIAGNOSTIC_TEST

The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)

A brief individually administered battery to measure cognitive decline or improvement across five domains in ages 12 to 89 years 11 months.

DIAGNOSTIC_TEST

the Mississippi Aphasia Screening Test

he Mississippi Aphasia Screening Test (MAST) was developed as a brief, repeatable screening measure for individuals with severely impaired communication/language skills.

DIAGNOSTIC_TEST

Amnesia Light and Brief Assessment (ALBA)

Very brief test used to measure deficits of more cognitive functions (short-term, episodic, semantic amnesia, sensory and motor aphasia, apraxia, psychomotor speed).

DIAGNOSTIC_TEST

The Picture naming and immediate recall test (PICNIR)

Very brief test used to measure deficits of more cognitive functions (short-term, episodic, semantic amnesia, sensory and motor aphasia, apraxia, psychomotor speed).

DIAGNOSTIC_TEST

Geriatric Depression Scale (GDS-15)

The Geriatric Depression Scale (GDS-15), used to screen for depression in adults aged 55 and older, consists of 15 items that assess mental health based on feelings over the past week.

DIAGNOSTIC_TEST

The Beck Anxiety Inventory (BAI)

A formative assessment and rating scale of anxiety.

DIAGNOSTIC_TEST

Digitial Diagnostics of Dementia (DDD)

Our experimental screening battery developed for this study.

Sponsors & Collaborators

• Faculty Hospital Kralovske Vinohrady

  lead OTHER_GOV

Principal Investigators

• Luboš Šmídl, Ing. Ph.D. · Západočeská univerzita v Plzni / Fakulta aplikovaných věd

• Jan Švec, Ing. Ph.D. · Západočeská univerzita v Plzni / Fakulta aplikovaných věd

• Filip Polák, Ing. · Západočeská univerzita v Plzni / Fakulta aplikovaných věd

• Aleš Bartoš, prof. MUDr. Ph.D. · Fakultní nemocnice Královské Vinohrady

• Martin Víta, Mgr. Ph.D. · Fyzikální ústav AV ČR, v. v. i.

• Marie Kompasová, Mgr. · Univerzita Karlova, Fakultní nemocnice Královské Vinohrady

• Michaela Zapletalová, Mgr. · Univerzita Palackého, Fakultní nemocnice Královské Vinohrady

Study Design

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

40 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-09-01

Primary Completion

2025-12-31

Completion

2026-08-31

Countries

• Czechia

Study Locations