MedTrace Logo

Metagenomic Analysis and Postoperative Pain in Infected Root Canals Using Different Irrigation Protocols

NCT07546773 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2026-05-04

No results posted yet for this study

Summary

Achieving effective root canal disinfection while minimizing postoperative pain is a critical goal in endodontic therapy. Advanced irrigation protocols, such as ultrasonic activation, laser activation, negative pressure irrigation (PulpSucker device), and mechanical activation (Easy Clean device), have shown promise in enhancing bacterial reduction within the root canal system. However, their impact on postoperative pain has not been fully explored.

This randomized controlled clinical trial aims to compare bacterial reduction and postoperative pain levels in infected root canals using four different irrigation protocols. The study will use metagenomic analysis to evaluate changes in bacterial community composition and the Visual Analogue Scale (VAS) to assess patient-reported pain levels at multiple time points postoperatively.

Conditions

  • Dental Pulp Necrosis
  • Pulpitis

Interventions

PROCEDURE

Ultrasonic Irrigation Activation

Sodium hypochlorite irrigation activated with ultrasonic device

PROCEDURE

Laser-Activated Irrigation

Laser-activated sodium hypochlorite with methylene blue photosensitizer

PROCEDURE

Mechanical Irrigation Activation

Mechanical activation device creating swirling motion

PROCEDURE

Negative Pressure Irrigation

Continuous irrigation with negative pressure suction

Sponsors & Collaborators

  • Suez Canal University

    lead OTHER

Principal Investigators

  • Salah El-Din Mohamed Abdallah, Professor, PhD · Professor of Microbiology, Faculty of Pharmacy, Suez Canal University

  • Hayam Youssef Hassan, Professor, PhD · Professor of Endodontics, Faculty of Dentistry, Suez Canal University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-04-30
Primary Completion
2027-08-15
Completion
2028-01-15

Countries

  • Egypt

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07546773 on ClinicalTrials.gov