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Effect of Different Irrigation Protocols on Postoperative Endodontic Pain and Inflammation

NCT07116252 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 75

Last updated 2025-08-11

No results posted yet for this study

Summary

This study aims to improve the postoperative endodontic outcome by assessing the effect of different irrigants on postoperative endodontic pain and their anti-inflammatory effects.

Conditions

  • Irrigation Solution
  • Postoperative Pain
  • Inflammation
  • Endodontic Treatment

Interventions

PROCEDURE

EDTA

17% EDTA as a final rinse after instrumentaion (sequential chelation)

PROCEDURE

Etidronate

9% HEBP as a final rinse after instrumentation (sequential chelation)

PROCEDURE

clodronate

0.26 M (7.6%) clodronate as a final rinse after instrumentation (sequential chelation)

PROCEDURE

Etidronic acid /sodium hypochlorite

(2.5% NaOCl + 9% HEBP) during instrumentation and as a final rinse after instrumentation (continous chelation)

PROCEDURE

clodronate + sodium hypochlorite

2.5% NaOCl + 0.26 M (7.6%) clodronate during instrumentation and as a final rinse after instrumentation (continuous chelation)

Sponsors & Collaborators

  • Suez Canal University

    lead OTHER

Principal Investigators

  • Dalia Fayyad · Professor of endodontics, faculty of dentistry, Suez Canal University

  • Dalia Abdallah · Associate Professor of endodontics, faculty of dentistry, Suez Canal University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-08-20
Primary Completion
2025-09-30
Completion
2025-12-31

Countries

  • Egypt

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07116252 on ClinicalTrials.gov