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Evaluating The Use of CGF Plugs in Fresh Odontectomy Socket.

NCT07542795 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2026-04-21

No results posted yet for this study

Summary

This study evaluates the use of Concentrated Growth Factor (CGF) plugs-a third-generation healing material made from the patient's own blood-to improve recovery after simple tooth extractions. CGF contains a dense matrix of growth factors and regenerative cells designed to enhance wound healing and tissue regeneration.

Participants requiring a single, non-surgical tooth extraction will have a CGF plug placed into the empty socket immediately following the procedure. The researchers will then monitor two main factors:

* Post-operative Pain: Patients will record their pain levels on a scale of 0 to 10 at 1, 3, and 7 days after the extraction.
* Bone Density: Using specialized imaging (CBCT), the researchers will measure how well the bone heals and fills the socket immediately after the procedure and again at 3 months.

The goal of this research is to determine if CGF plugs can effectively reduce patient discomfort and help preserve bone density, which is critical for future dental treatments like implants.

Conditions

  • Odontectomy (Tooth Extraction)
  • Socket Preservation and Healing Following Simple, Non-surgical Extraction
  • Alveolar Bone Density and Postoperative Pain Management
  • Periapical Radiolucency

Interventions

OTHER

Concentrated Growth Factor (CGF) Plug

The intervention involves preparing an autologous Concentrated Growth Factor (CGF) plug from the patient's blood using variable-speed centrifugation and placing it into a fresh, curetted extraction socket to evaluate its impact on bone density and postoperative pain.

Sponsors & Collaborators

  • Cairo University

    lead OTHER

Principal Investigators

  • Hisham Sayed, Professor · Cairo University

  • Abdelmoez Mohamed El-Sharkawy, Associate Professor · Cairo University

  • Aziz Taysir Haydar · Cairo University

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
20 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-09-28
Primary Completion
2026-12-01
Completion
2026-12-30

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07542795 on ClinicalTrials.gov