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Radiographic And Histomorphometric Assessment Following Alveolar Ridge Preservation Using Chitosan Gel Versus Normal Socket Healing In Posterior Maxillary and Mandibular Region

NCT07571863 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 26

Last updated 2026-05-06

No results posted yet for this study

Summary

After tooth extraction, the alveolar bone, which supports the teeth, undergoes a natural resorption process. This bone loss can be significant, especially in the first few months post-extraction, leading to a reduction in both bone height and width. This resorption can compromise the structural foundation required for future dental restorations, such as implants, bridges, or dentures.

Socket preservation technique has been proposed since years as a technique to preserve alveolar bone following extraction and has proved excellent clinical efficacy over years.

Several materials have been proposed for alveolar ridge preservation, such as autografts, allografts, xenografts, and alloplasts, each with its own set of advantages and limitations. However, these materials may have limitations, including potential immunogenic responses and variable integration.

Thus, there is always a need to explore and validate new materials to mitigate these issues. This study aims to tests one of these new materials named chitosan gel to investigate whether the application of this chitosan gel following posterior mandibular tooth extraction would better preserve alveolar ridge dimensions and improve bone quality compared to normal socket healing or not ?.

Conditions

  • Alveolar Ridge Preservation
  • Socket Preservation
  • Wound Healing

Interventions

PROCEDURE

Chitosan gel Sigma-Aldrich® in socket preservation

The interventional group, involves the application of Chitosan gel extract to the extraction socket immediately after tooth extraction. The procedure includes performing the tooth extraction using standard techniques, applying Chitosan gel extract directly into the extraction socket, covering the socket with gelfoam in place, suturing the site stabilized in situ with a Vicryl Plus external criss-cross inverting horizontal mattress suture to ensure stability and containment of the Chitosan gel extract, and following standard postoperative care instructions. Specimen preparation and histomorphometric analysis.

PROCEDURE

Gelfoam® absorbable gelatin sponge in socket preservation post extraction

The control group, involves allowing the extraction socket to heal naturally without any additional intervention. The procedure includes performing the tooth extraction using standard techniques, allowing the socket to heal without the application of any grafting materials or membranes, and following standard postoperative care instructions to maintain oral hygiene and manage pain. Postoperative Care and follow up: (Elfana et al., 2021)

Sponsors & Collaborators

  • Cairo University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-12-04
Primary Completion
2025-10-01
Completion
2025-11-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07571863 on ClinicalTrials.gov