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Evaluating The Use of CGF Made Plugs in Mandibular Extraction Sites of Lower Impacted 3rd Molars.

NCT07484997 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2026-04-08

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if Concentrated Growth Factor (CGF) plugs help improve bone healing and reduce pain after the surgical removal of impacted lower third molars.

The study aims to answer the following:

Does packing CGF plugs into the extraction site improve bone density? Does the use of CGF plugs reduce postoperative pain for the patient?

Researchers will evaluate the healing outcomes of patients receiving this treatment in a prospective case series study. Because this is a case series, all participants will receive the CGF plug intervention rather than being compared to a placebo group.

Participants in this study will:

Undergo a blood draw to create the autologous CGF plug from their own growth factors.

Undergo the surgical extraction of an impacted lower third molar under local anesthesia.

Have a CGF plug placed in the extraction socket immediately following the tooth removal.

Report their pain levels using a numeric scale on Day 1, Day 3, and Day 7 after surgery.

Return for a follow-up CBCT scan three months after the procedure to evaluate bone density changes.

Conditions

  • Impacted Lower Third Molar
  • Alveolar Bone Regeneration Following Odontectomy
  • Postoperative Pain Management in Oral Surgery
  • Concentrated Growth Factor for Extraction Socket Healing

Interventions

OTHER

Concentrated Growth Factor (CGF) Plug

This is a third-generation autologous blood concentrate prepared using a dedicated centrifugation system. The process creates a fibrin-rich organic matrix from the patient's own blood, which is then molded into a plug form and packed into the fresh extraction socket to enhance healing.

Sponsors & Collaborators

  • Cairo University

    lead OTHER

Principal Investigators

  • Abdelmoez Mohamed El-Sharkawy, Associate Professor · Cairo University

  • Meshari Mohammed Aharbi · Cairo University

  • Khalid Elhayes, Professor · Cairo University

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-05-01
Primary Completion
2026-09-01
Completion
2026-12-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07484997 on ClinicalTrials.gov