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Effect of oXiris Hemofilter Use in Septic Shock: A Multicenter Retrospective Cohort Study

NCT07539883 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 360

Last updated 2026-04-20

No results posted yet for this study

Summary

This study aims to evaluate the clinical effectiveness of the oXiris® hemofilter in patients with septic shock and acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). While some studies suggest that oXiris® may improve hemodynamic stability by removing endotoxins and cytokines, its impact on survival remains inconsistent.To provide more reliable causal evidence, this multicenter retrospective cohort study utilizes a Target Trial Emulation (TTE) approach. The study will compare patients treated with the oXiris® filter to those treated with standard CRRT filters, focusing on in-hospital mortality and other clinical outcomes such as fluid balance and vasopressor requirements.

Conditions

  • Septic Shock
  • Multiorgan Failure
  • Sepsis

Sponsors & Collaborators

  • Vantive Health LLC

    collaborator INDUSTRY

  • Seoul National University Bundang Hospital

    lead OTHER

Principal Investigators

  • Sung Yoon Lim, MD.PhD · Seoul National University Bundang Hospital

Eligibility

Min Age
19 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-22
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • South Korea

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07539883 on ClinicalTrials.gov