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Microbiome and Metabolome Profiles in Couples Undergoing IVF and Reproductive Outcomes

NCT07532629 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1000

Last updated 2026-04-16

No results posted yet for this study

Summary

This prospective observational cohort study investigates the role of the microbiome and metabolome in couples undergoing in vitro fertilization. Biological samples will be collected from both female and male partners, including semen, vaginal, and blood samples, to characterize microbial composition and metabolic profiles. The study aims to examine how these biological profiles are associated with reproductive outcomes such as fertilization, pregnancy, miscarriage, and live birth. Participants will be followed longitudinally, and reproductive and obstetric outcomes will be obtained through linkage with national health registers.

Conditions

  • Infertility
  • Assisted Reproductive Technology
  • Pregnancy Complications
  • Pregnancy Loss, Early
  • Metabolome
  • Microbiome

Sponsors & Collaborators

Principal Investigators

  • Kenny A. Rodriguez-Wallberg, MD., PhD · Oncology-pathology, Karolinska Institutet

  • Hana Shabana, MD, PhD candidate · Karolinska Institutet

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-06-10
Primary Completion
2028-08-20
Completion
2029-03-01

Countries

  • Sweden

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07532629 on ClinicalTrials.gov