MedTrace Logo

Effect of Different Meal Types Given Before Exercise on Plasma Amino Acid Levels and Metabolic Control Parameters in Classical Phenylketonuria Patients Undergoing Aerobic and Resistance Exercises

NCT07526909 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2026-04-16

No results posted yet for this study

Summary

This study will be the first in the literature to evaluate the relationship between aerobic and resistance exercises, plasma amino acid levels, metabolic control of patients, and the metabolic response to exercise with different types of meals in patients with Phenylketonuria (PKU). In patients with phenylketonuria, the aim is to determine which pre-exercise dietary recommendations are more physiologically appropriate and ideal for achieving good metabolic control.

In the literature, there are very few studies examining the effects of exercise on plasma amino acid levels and metabolic parameters in PKU patients.

Conditions

Interventions

BEHAVIORAL

Aerobic Exercise

Participants performed 30 minutes of moderate-intensity aerobic exercise on a treadmill at 80% of maximum heart rate with a 3% incline.

BEHAVIORAL

Resistance Exercise

Participants performed a resistance exercise session including 3 sets of 10 repetitions of crunch, push-up, forward lunge, and squat exercises.

OTHER

Water

Participants consumed 200 ml of water prior to the exercise session.

DIETARY_SUPPLEMENT

Carbohydrates

Participants consumed carbohydrates at a dose of 1 g/kg/hour prior to the exercise session.

DIETARY_SUPPLEMENT

Protein

Participants consumed protein equivalent to 0.4 g/kg/hour (amino acids) prior to the exercise session.

Sponsors & Collaborators

  • Hacettepe University

    lead OTHER

Principal Investigators

  • SERAP SIVRI, Professor, MD · Hacettepe University

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-10-01
Primary Completion
2026-05-31
Completion
2026-07-15

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07526909 on ClinicalTrials.gov