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Acute and Chronic Effects of Obesity

NCT07515547 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2026-04-07

No results posted yet for this study

Summary

The goal of this study is to understand if there are differences in the fat, muscle and metabolism of individuals who developed obesity during childhood versus those who developed obesity in adulthood. We will do this by having recruited participants undergo subcutaneous adipose tissue biopsies in the abdomen and thigh, a muscle biopsy in the thigh, collect blood and urine samples, a DEXA scan and 3 submaximal exercise tests. participants will also have their resting energy expenditure measured through indirect calorimetry to tailor a targeted weight loss protocol through caloric restriction and cardiovascular exercise (3 times a week). After 10% of weight loss is completed, study participants will repeat all tests during a 2 week weight stabilization period. At 12 weeks into the intervention, indirect calorimetry, DEXA scan and blood tests will be repeated.

Conditions

  • Obesity & Overweight
  • Metabolism Changes
  • Lipid Metabolism

Interventions

BEHAVIORAL

Weight loss

A conventional weight loss program will be implemented for participants to lose approximately 10% of their starting body weight

Sponsors & Collaborators

  • Montreal Children's Hospital of the MUHC

    collaborator OTHER

  • Concordia University, Montreal

    lead OTHER

Principal Investigators

  • Sylvia Santosa · Concordia University, Montreal

Eligibility

Min Age
25 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-04-30
Primary Completion
2029-08-31
Completion
2029-08-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07515547 on ClinicalTrials.gov