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Decontamination Methods in the Treatment of Peri-implantitis

NCT07500844 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 64

Last updated 2026-04-03

No results posted yet for this study

Summary

The goal of this clinical study is to compare the effectiveness of different methods for decontaminating dental implant surfaces in the treatment of peri-implantitis. The main question it aims to answer is:

Which combination of an antiseptic solution and an air-polishing powder is most effective for the non-surgical treatment of peri-implantitis? Researchers will compare three different treatment combinations (Miramistin with sodium bicarbonate, chlorhexidine with erythritol, and Octenisept with glycine) in patients diagnosed with peri-implantitis. Participants will receive the combined treatment at intervals of 7-10 days for one month. The study will assess changes in probing depth, bleeding, and bone loss at 1 and 2.5 months after treatment to determine the most effective and balanced approach for preserving implant surfaces and promoting tissue healing.

Conditions

  • Peri-implantitis

Interventions

DRUG

Miramistin

Antiseptic solution (0.01%) used for irrigation of the peri-implant pocket.

PROCEDURE

Sodium Bicarbonate Powder

Abrasive powder used for air-polishing debridement of the implant surface at a 45-degree angle

DRUG

Chlorhexidine

Antiseptic solution (0.05%) used for irrigation of the peri-implant pocket.

PROCEDURE

Erythritol Powder

Abrasive powder used for air-polishing debridement of the implant surface at a 45-degree angle.

DRUG

Octenisept

Antiseptic solution used for irrigation of the peri-implant pocket.

PROCEDURE

Glycine Powder

Abrasive powder used for air-polishing debridement of the implant surface at a 45-degree angle.

Sponsors & Collaborators

  • Research Centre for Medical Genetics, Russian Federation

    lead OTHER_GOV

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
21 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-02-01
Primary Completion
2025-11-30
Completion
2025-12-11

Countries

  • Russia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07500844 on ClinicalTrials.gov